TNO Pharma Home Page

CONTACT
ENGLISH
Ex vivo Organ model

PRECLINICAL DMPK APPLICATIONS
NORMOTHERMIC PERFUSED PORCINE ORGANS
CONTRACT SERVICE, TECHNOLOGIES OPEN FOR PARTNERING

Ex vivo whole liver normothermic machine perfusion model

サンプルイメージ Prediction First Pass Liver Effects Biliary Excretion and DDI

  健康なブタの肝臓全体を常温機械潅流し下記項目の測定を実施します。
      (受託研究対象モデル)
      > Hepatic Clearance
      > Hepatic Metabolism
      > Biliary Excretion
      > Plasma Exposure upon DDI
  > Dosing to portal vein and/or hepatic artery

  生体肝移植を受ける患者さんから摘出した肝臓を常温機械潅流し
    以下の測定、解析をする取組みを進めています。
      (共同研究対象モデル)
      > Hepatic Clearance
      > Hepatic Metabolism
      > Biliary Excretion
      > Plasma Exposure upon DDI
  > Dosing to portal vein and/or hepatic artery
  > NASH: Biomarker detection / Target Binding

  技術資料ダウンロード:
  Normothermic Machine Perfusion of Diseased Explanted Livers to Study Hepatic Pharmacokinetic Processes (Poster at ISSX-2021)
  Ex vivo whole liver perfusion model for prediction of drug drug interactions and biliary excretion of Rosuvastatin (Poster)
  Pharmacokinetics Application of Normothermic Perfused Ex Vivo Porcine Livers (Poster at ISSX-2019)

Ex vivo Kidney perfusion model

サンプルイメージ To study Renal Clearance of Drugs
  健康なブタの腎臓器全体を常温機械潅流し下記項目の測定を実施します。
  研究課題例;
> Infusion of drug cocktail to study renal clearance of probe drug cocktail (0 - 120 min)
> Study DDI at the renal level by infusing probe + inhibitor cocktail mix (125- 245 min)
> Perfusate and urine drug profiles
  Readout例;
      > Flow (pressure driven machine)
      > Inulin clearance
      > Urine production
      > Ad hoc viability analysis
        > Perfusate: pO2, pCO2, pH, sO2, ureum,creatinin, Na, K
      > Albumin (in perfusate and urine)
      > Biopsy: before, during & end of perfusion

Combined Liver and Kidney perfusion model

サンプルイメージ To study Clearance of Probe Drug Cocktail via Biliary and Renal Clearance route
  Determine % of biliary and % renal excretion of drugs
  Ability to perfuse for longer time
  Open for Partnering


CONTACT
ページトップへ戻る