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Ex vivo Organ model

PRECLINICAL DMPK APPLICATIONS
NORMOTHERMIC PERFUSED PORCINE ORGANS
CONTRACT SERVICE, TECHNOLOGIES OPEN FOR PARTNERING

Ex vivo whole liver normothermic machine perfusion model

サンプルイメージ

Prediction of First Pass Liver Effects, Biliary Excretion and DDI
   Porcine Liver model (for contract research)
      > Hepatic Clearance
      > Hepatic Metabolism
      > Biliary Excretion
      > Plasma Exposure upon DDI
      > Dosing to portal vein and/or hepatic artery

   Human Liver model (for collaboration research)
      > Hepatic Clearance
      > Hepatic Metabolism
      > Biliary Excretion
      > Plasma Exposure upon DDI
      > Dosing to portal vein and/or hepatic artery
      > NASH: Biomarker detection / Target Binding

  Download:
  Normothermic Machine Perfusion of Diseased Explanted Livers to Study Hepatic Pharmacokinetic Processes (Poster at ISSX-2021)
  Ex vivo whole liver perfusion model for prediction of drug drug interactions and biliary excretion of Rosuvastatin (Poster)
  Pharmacokinetics Application of Normothermic Perfused Ex Vivo Porcine Livers. Poster ISSX-2019

Ex vivo Kidney perfusion model

サンプルイメージ TO STUDY RENAL CLEARANCE OF DRUGS
  Experimental set up;
> Infusion of drug cocktail to study renal clearance of probe drug cocktail (0 - 120 min)
> Study DDI at the renal level by infusing probe + inhibitor cocktail mix (125- 245 min)
> Perfusate and urine drug profiles

  Measurement;
      > Flow (pressure driven machine)
      > Inulin clearance
      > Urine production
      > Ad hoc viability analysis
        > Perfusate: pO2, pCO2, pH, sO2, ureum,creatinin, Na, K
      > Albumin (in perfusate and urine)
      > Biopsy: before, during & end of perfusion

Combined Liver and Kidney perfusion model

サンプルイメージ To study Clearance of Probe Drug Cocktail via Biliary and Renal Clearance route
  Determine % of biliary and % renal excretion of drugs
  Ability to perfuse for longer time
  Open for Partnering


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